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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

5-Aryl-3-(alkylthio)-4H-1, 2, 4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents

…, JH Kehne, HJ Ketteler, TC McCloskey

文献索引：Kane; Staeger; Dalton; Miller; Dudley; Ogden; Kehne; Ketteler; McCloskey; Senyah; Chmielewski Journal of Medicinal Chemistry, 1994 , vol. 37, # 1 p. 125 - 132

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被引用次数: 54

摘要

Selected examples from three series of isomeric (alkylthio)-1, 2, 4-triazoles were prepared and examined for anticonvulsant activity versus strychnine-, maximal-electroshock-, pentylenetetrazole-, and 3-mercaptopropionic-acid-induced seizures in mice. A number of B- aryl-3-(alkylthio)-4H-1, 2, 4-triazoles were selective antagonists of strychnine-induced convulsions. The isomeric 3-aryl-5-(alkylthio)-and 5-aryl-3-(alkylthio)-lH-l, 2, 4-triazoles ...

5-(4-氯苯基)-4-乙基-4H-[1,2,4]噻唑-3-硫醇结构式

5-(4-氯苯基)-4-乙基-...

碘甲烷结构式

~79%

3-(4-Chlorophenyl)-4-ethyl-5-(methylthio)-4H-1,2,4-triazole结构式

3-(4-Chlorophen...

未登录结构式

~%

3-(4-Chlorophenyl)-4-ethyl-5-(methylthio)-4H-1,2,4-triazole结构式

3-(4-Chlorophen...

4-氯苯甲酰氯结构式

4-氯苯甲酰氯

~%

3-(4-Chlorophenyl)-4-ethyl-5-(methylthio)-4H-1,2,4-triazole结构式

3-(4-Chlorophen...

未登录结构式

碘甲烷结构式

~43%

1-methyl-3-methylsulfanyl-5-phenyl-1,2,4-triazole结构式

1-methyl-3-meth...

4-triazole-3-thiol,5-(p-chlorophenyl)-4-methyl-4h-2结构式

4-triazole-3-th...

碘甲烷结构式

~72%

3-(4-chlorophenyl)-4-methyl-5-methylsulfanyl-1,2,4-triazole结构式

3-(4-chlorophen...

2-(4-chlorobenzoyl)-N-methylhydrazinecarbothioamide结构式

2-(4-chlorobenz...

~%

3-(4-chlorophenyl)-4-methyl-5-methylsulfanyl-1,2,4-triazole结构式

3-(4-chlorophen...

4-氯苯甲酰肼结构式

4-氯苯甲酰肼

~%

3-(4-chlorophenyl)-4-methyl-5-methylsulfanyl-1,2,4-triazole结构式

3-(4-chlorophen...

KM02894结构式

~76%

4-甲基-5-(2-噻吩)-4H-1,2,4-噻唑-3-硫醇结构式

4-甲基-5-(2-噻吩)-4...

5-(4-chlorophenyl)-2-methyl-1H-1,2,4-triazole-3-thione结构式

5-(4-chlorophen...

碘甲烷结构式

~60%

3-(4-chlorophenyl)-1-methyl-5-methylsulfanyl-1,2,4-triazole结构式

3-(4-chlorophen...

2-methyl-5-phenyl-2,4-dihydro-[1,2,4]triazole-3-thione结构式

2-methyl-5-phen...

碘甲烷结构式

~75%

1-methyl-5-methylsulfanyl-3-phenyl-1,2,4-triazole结构式

1-methyl-5-meth...

未登录结构式

~74%

5-(2-氯苯基)-4-甲基-4H-1,2,4-噻唑-3-硫醇结构式

5-(2-氯苯基)-4-甲基-...

2-氯苯甲酰肼结构式

2-氯苯甲酰肼

~%

5-(2-氯苯基)-4-甲基-4H-1,2,4-噻唑-3-硫醇结构式

5-(2-氯苯基)-4-甲基-...

5-苯基-4-甲基-4氢-3-羟基-1,2,4-三唑结构式

5-苯基-4-甲基-4氢-3-...

碘甲烷结构式

~70%

4-甲基-3-甲基硫代-5-苯基-4H-1,2,4-噻唑结构式

4-甲基-3-甲基硫代-5-苯...

苯甲酰肼结构式

~%

4-甲基-3-甲基硫代-5-苯基-4H-1,2,4-噻唑结构式

4-甲基-3-甲基硫代-5-苯...

未登录结构式

~69%

5-(4-氟苯基)-4-甲基-4H-1,2,4-三唑-3-硫醇结构式

5-(4-氟苯基)-4-甲基-...

4-甲基-5-(2-噻吩)-4H-1,2,4-噻唑-3-硫醇结构式

4-甲基-5-(2-噻吩)-4...

碘甲烷结构式

~63%

4-methyl-3-methylsulfanyl-5-thiophen-2-yl-1,2,4-triazole结构式

4-methyl-3-meth...

2-噻吩甲酰肼结构式

2-噻吩甲酰肼

~%

4-methyl-3-methylsulfanyl-5-thiophen-2-yl-1,2,4-triazole结构式

4-methyl-3-meth...

KM02894结构式

~%

4-methyl-3-methylsulfanyl-5-thiophen-2-yl-1,2,4-triazole结构式

4-methyl-3-meth...

5-(4-METHOXYPHENYL)-4-METHYL-4H-1,2,4-TRIAZOLE-3-THIOL结构式

5-(4-METHOXYPHE...

碘甲烷结构式

~68%

3-(4-methoxyphenyl)-4-methyl-5-methylsulfanyl-1,2,4-triazole结构式

3-(4-methoxyphe...

1-(4-methoxy-benzoyl)-4-methyl thiosemicarbazide结构式

1-(4-methoxy-be...

~%

3-(4-methoxyphenyl)-4-methyl-5-methylsulfanyl-1,2,4-triazole结构式

3-(4-methoxyphe...

对甲氧基苯甲酰肼结构式

对甲氧基苯甲酰肼

~%

3-(4-methoxyphenyl)-4-methyl-5-methylsulfanyl-1,2,4-triazole结构式

3-(4-methoxyphe...

4-甲基-5-(4-甲基苯基)-4H-1,2,4-噻唑-3-硫醇结构式

4-甲基-5-(4-甲基苯基)...

碘甲烷结构式

~62%

4-methyl-3-(4-methylphenyl)-5-methylsulfanyl-1,2,4-triazole结构式

4-methyl-3-(4-m...

对甲苯肼结构式

~%

4-methyl-3-(4-methylphenyl)-5-methylsulfanyl-1,2,4-triazole结构式

4-methyl-3-(4-m...

N-methyl-2-(4-methylbenzoyl)hydrazinecarbothioamide结构式

N-methyl-2-(4-m...

~%

4-methyl-3-(4-methylphenyl)-5-methylsulfanyl-1,2,4-triazole结构式

4-methyl-3-(4-m...

5-(3-fluorophenyl)-4-methyl-2,4-dihydro-3H-1,2,4-triazole-3-thione结构式

5-(3-fluorophen...

碘甲烷结构式

~72%

3-(3-fluorophenyl)-4-methyl-5-methylsulfanyl-1,5-dihydro-1,2,4-triazole结构式

3-(3-fluorophen...

3-氟苯甲酰氯结构式

3-氟苯甲酰氯

~%

3-(3-fluorophenyl)-4-methyl-5-methylsulfanyl-1,5-dihydro-1,2,4-triazole结构式

3-(3-fluorophen...

2-(4-chlorobenzoyl)-N-methylhydrazinecarbothioamide结构式

2-(4-chlorobenz...

~30%

4-triazole-3-thiol,5-(p-chlorophenyl)-4-methyl-4h-2结构式

4-triazole-3-th...