e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

5-Aryl-3-(alkylthio)-4H-1, 2, 4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents

…, JH Kehne, HJ Ketteler, TC McCloskey

Index: Kane; Staeger; Dalton; Miller; Dudley; Ogden; Kehne; Ketteler; McCloskey; Senyah; Chmielewski Journal of Medicinal Chemistry, 1994 , vol. 37, # 1 p. 125 - 132

Full Text: HTML

Citation Number: 54

Abstract

Selected examples from three series of isomeric (alkylthio)-1, 2, 4-triazoles were prepared and examined for anticonvulsant activity versus strychnine-, maximal-electroshock-, pentylenetetrazole-, and 3-mercaptopropionic-acid-induced seizures in mice. A number of B- aryl-3-(alkylthio)-4H-1, 2, 4-triazoles were selective antagonists of strychnine-induced convulsions. The isomeric 3-aryl-5-(alkylthio)-and 5-aryl-3-(alkylthio)-lH-l, 2, 4-triazoles ...

5-(4-CHLORO-PHENYL)-4-ETHYL-4H-[1,2,4]TRIAZOLE-3-THIOL Structure

5-(4-CHLORO-PHE...

methyl iodide Structure

~79%

3-(4-Chlorophenyl)-4-ethyl-5-(methylthio)-4H-1,2,4-triazole Structure

3-(4-Chlorophen...

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N/A Structure

~%

3-(4-Chlorophenyl)-4-ethyl-5-(methylthio)-4H-1,2,4-triazole Structure

3-(4-Chlorophen...

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4-Chlorobenzoyl chloride Structure

4-Chlorobenzoyl...

~%

3-(4-Chlorophenyl)-4-ethyl-5-(methylthio)-4H-1,2,4-triazole Structure

3-(4-Chlorophen...

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N/A Structure

methyl iodide Structure

~43%

1-methyl-3-methylsulfanyl-5-phenyl-1,2,4-triazole Structure

1-methyl-3-meth...

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4-triazole-3-thiol,5-(p-chlorophenyl)-4-methyl-4h-2 Structure

4-triazole-3-th...

methyl iodide Structure

~72%

3-(4-chlorophenyl)-4-methyl-5-methylsulfanyl-1,2,4-triazole Structure

3-(4-chlorophen...

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2-(4-chlorobenzoyl)-N-methylhydrazinecarbothioamide Structure

2-(4-chlorobenz...

~%

3-(4-chlorophenyl)-4-methyl-5-methylsulfanyl-1,2,4-triazole Structure

3-(4-chlorophen...

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4-chlorobenzhydrazide Structure

4-chlorobenzhyd...

~%

3-(4-chlorophenyl)-4-methyl-5-methylsulfanyl-1,2,4-triazole Structure

3-(4-chlorophen...

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KM02894 Structure

~76%

4-METHYL-5-(2-THIENYL)-4H-1,2,4-TRIAZOLE-3-THIOL Structure

4-METHYL-5-(2-T...

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5-(4-chlorophenyl)-2-methyl-1H-1,2,4-triazole-3-thione Structure

5-(4-chlorophen...

methyl iodide Structure

~60%

3-(4-chlorophenyl)-1-methyl-5-methylsulfanyl-1,2,4-triazole Structure

3-(4-chlorophen...

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2-methyl-5-phenyl-2,4-dihydro-[1,2,4]triazole-3-thione Structure

2-methyl-5-phen...

methyl iodide Structure

~75%

1-methyl-5-methylsulfanyl-3-phenyl-1,2,4-triazole Structure

1-methyl-5-meth...

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1-[(2-Chlorobenzoyl)amino]-3-methylthiourea Structure

1-[(2-Chloroben...

~74%

5-(2-CHLOROPHENYL)-4-METHYL-4H-1,2,4-TRIAZOLE-3-THIOL Structure

5-(2-CHLOROPHEN...

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2-Chlorobenzohydrazide Structure

2-Chlorobenzohy...

~%

5-(2-CHLOROPHENYL)-4-METHYL-4H-1,2,4-TRIAZOLE-3-THIOL Structure

5-(2-CHLOROPHEN...

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4-methyl-3-phenyl-1H-1,2,4-triazole-5-thione Structure

4-methyl-3-phen...

methyl iodide Structure

~70%

4-methyl-3-methylsulfanyl-5-phenyl-1,2,4-triazole Structure

4-methyl-3-meth...

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Benzohydrazide Structure

~%

4-methyl-3-methylsulfanyl-5-phenyl-1,2,4-triazole Structure

4-methyl-3-meth...

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N/A Structure

~69%

5-(4-Fluorophenyl)-4-methyl-4H-1,2,4-triazole-3-thiol Structure

5-(4-Fluorophen...

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4-METHYL-5-(2-THIENYL)-4H-1,2,4-TRIAZOLE-3-THIOL Structure

4-METHYL-5-(2-T...

methyl iodide Structure

~63%

4-methyl-3-methylsulfanyl-5-thiophen-2-yl-1,2,4-triazole Structure

4-methyl-3-meth...

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2-Thiophenecarbohydrazide Structure

2-Thiophenecarb...

~%

4-methyl-3-methylsulfanyl-5-thiophen-2-yl-1,2,4-triazole Structure

4-methyl-3-meth...

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KM02894 Structure

~%

4-methyl-3-methylsulfanyl-5-thiophen-2-yl-1,2,4-triazole Structure

4-methyl-3-meth...

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5-(4-METHOXYPHENYL)-4-METHYL-4H-1,2,4-TRIAZOLE-3-THIOL Structure

5-(4-METHOXYPHE...

methyl iodide Structure

~68%

3-(4-methoxyphenyl)-4-methyl-5-methylsulfanyl-1,2,4-triazole Structure

3-(4-methoxyphe...

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1-(4-methoxy-benzoyl)-4-methyl thiosemicarbazide Structure

1-(4-methoxy-be...

~%

3-(4-methoxyphenyl)-4-methyl-5-methylsulfanyl-1,2,4-triazole Structure

3-(4-methoxyphe...

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4-Methoxybenzohydrazide Structure

4-Methoxybenzoh...

~%

3-(4-methoxyphenyl)-4-methyl-5-methylsulfanyl-1,2,4-triazole Structure

3-(4-methoxyphe...

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4-methyl-3-(4-methylphenyl)-1H-1,2,4-triazole-5-thione Structure

4-methyl-3-(4-m...

methyl iodide Structure

~62%

4-methyl-3-(4-methylphenyl)-5-methylsulfanyl-1,2,4-triazole Structure

4-methyl-3-(4-m...

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Benzoic acid,4-methyl-, hydrazide Structure

Benzoic acid,4-...

~%

4-methyl-3-(4-methylphenyl)-5-methylsulfanyl-1,2,4-triazole Structure

4-methyl-3-(4-m...

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N-methyl-2-(4-methylbenzoyl)hydrazinecarbothioamide Structure

N-methyl-2-(4-m...

~%

4-methyl-3-(4-methylphenyl)-5-methylsulfanyl-1,2,4-triazole Structure

4-methyl-3-(4-m...

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5-(3-fluorophenyl)-4-methyl-2,4-dihydro-3H-1,2,4-triazole-3-thione Structure

5-(3-fluorophen...

methyl iodide Structure

~72%

3-(3-fluorophenyl)-4-methyl-5-methylsulfanyl-1,5-dihydro-1,2,4-triazole Structure

3-(3-fluorophen...

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3-Fluorobenzoyl chloride Structure

3-Fluorobenzoyl...

~%

3-(3-fluorophenyl)-4-methyl-5-methylsulfanyl-1,5-dihydro-1,2,4-triazole Structure

3-(3-fluorophen...

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2-(4-chlorobenzoyl)-N-methylhydrazinecarbothioamide Structure

2-(4-chlorobenz...

~30%

4-triazole-3-thiol,5-(p-chlorophenyl)-4-methyl-4h-2 Structure

4-triazole-3-th...

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