Apoptosis

3-Nitro-naphthalimide and nitrogen mustard conjugate NNM-25 induces hepatocellular carcinoma apoptosis via PARP-1/p53 pathway

S Xie, Y Zhang, Q Li, F Xu, J Miao, J Zhao, C Wang

文献索引：Xie, Song-Qiang; Zhang, Ya-Hong; Li, Qian; Xu, Feng-Hua; Miao, Jiu-Wang; Zhao, Jin; Wang, Chao-Jie Apoptosis, 2012 , vol. 17, # 7 p. 725 - 734

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被引用次数: 19

摘要

Abstract Hepatocellular carcinoma (HCC) is one of the main causes of death in cancer. Some naphthalimide derivatives exert high anti-proliferative effects on HCC. In this study, it is confirmed that 3-nitro-naphthalimide and nitrogen mustard conjugate (NNM-25), a novel compound conjugated by NNM-25, displayed more potent therapeutic action on HCC, both in vivo and in vitro, than amonafide, a naphthalimide drug in clinical trials. More ...