Synthesis and biological evaluation of the 1, 5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1 H- …

TD Penning, JJ Talley, SR Bertenshaw…

文献索引：Journal of Medicinal Chemistry, , vol. 40, # 9 p. 1347 - 1365

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被引用次数: 1714

摘要

... Journal of Medicinal Chemistry. ... Chemistry. The spatial orientation of the two aromatic rings of the tricyclic inhibitor class was known to be critical for cyclooxygenase inhibition. We found that the two appropriately substituted ...