Tetrahedron letters

Microwave-assisted, efficient and regioselective Pd-catalyzed C-phenylation of halopyrimidines

SC Ceide, AG Montalban

文献索引：Ceide, Susana Conde; Montalban, Antonio Garrido Tetrahedron Letters, 2006 , vol. 47, # 26 p. 4415 - 4418

全文：HTML全文

被引用次数: 25

摘要

We herein report that flash heating microwave irradiation is a helpful tool in the formation of arylpyrimidines from the corresponding halopyrimidines. The palladium-catalyzed cross- coupling reactions of 2, 4-di-and 2, 4, 5-trihalopyrimidines with phenylboronic acid under the above conditions are described. By use of the appropriate catalyst and the adequate halopyrimidine, good regioselectivity can be achieved in the 2-, 4-, or 5-positions of the ...