Tetrahedron

Syntheses of substituted pyridines, quinolines and diazines via palladium-catalyzed cross-coupling of aryl Grignard reagents

…, F Mongin, F Trécourt, G Quéguiner, P Knochel

文献索引：Bonnet, Veronique; Mongin, Florence; Trecourt, Francois; Queguiner, Guy; Knochel, Paul Tetrahedron, 2002 , vol. 58, # 22 p. 4429 - 4438

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被引用次数: 101

摘要

The palladium-catalyzed cross-coupling reactions between arylmagnesium halides (phenylmagnesium chloride, mesitylmagnesium bromide, 4-(methoxycarbonyl) phenylmagnesium chloride and 4-cyanophenylmagnesium chloride) and halopyridines allowed the synthesis of substituted pyridines. Owing to the remarkably mild conditions used (often below 0° C), the reaction could be extended to the use of functionalized ...