Tetrahedron letters

Reductive amination of aldehydes and ketones by a Hantzsch dihydropyridine using scandium triflate as a catalyst

T Itoh, K Nagata, A Kurihara, M Miyazaki, A Ohsawa

文献索引：Itoh, Takashi; Nagata, Kazuhiro; Kurihara, Ayako; Miyazaki, Michiko; Ohsawa, Akio Tetrahedron Letters, 2002 , vol. 43, # 17 p. 3105 - 3108

全文：HTML全文

被引用次数: 83

摘要

Direct reductive amination 1 of aldehydes and ketones is a convenient method for the preparation of secondary and tertiary amines owing to its simple procedure, 2 and recent application of the reaction to combinatorial chemistry is gaining more attention. 3 The overall process involves the formation of an imine or iminium intermediate by condensation of aldehydes or ketones with amines, followed by in situ reduction to an alkylated amine. For the reducing agent, ...