前往化源商城

举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Synthesis of nevirapine and its major metabolite

…, J Vitous, S Campbell, J Adams

文献索引：Grozinger; Fuchs; Hargrave; Mauldin; Vitous; Campbell; Adams Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 1 p. 259 - 263

全文：HTML全文

被引用次数: 29

摘要

Abstract Several synthetic methods were developed during the process optimization for the large scale synthesis of nevirapine (1), a non-nucleoside inhibitor of HIV-1 Reverse Transcriptase. The synthesis of its putative major metabolite 11-cyclopropyl-5, 11-dihydro- ...

奈韦拉平结构式

~30%

11-环丙基-5,11-二氢-4-(羟甲基)-6H-联吡啶[3,2-b:2′,3′-e][1,4]二氮杂卓-6-酮结构式

11-环丙基-5,11-二氢-...

2-氯-3-吡啶羧酸结构式

2-氯-3-吡啶羧酸

2,6-二氯-4-甲基-3-氨基吡啶结构式

2,6-二氯-4-甲基-3-氨基吡啶

~87%

2-chloro-N-(2,6-dichloro-4-methylpyridin-3-yl)pyridine-3-carboxamide结构式

2-chloro-N-(2,6...

2,6-二氯-4-甲基烟酰胺结构式

2,6-二氯-4-甲基烟酰胺

~89%

2,6-二氯-4-甲基-3-氨基吡啶结构式

2,6-二氯-4-甲基-3-氨基吡啶

Synthesis of five nevirapine metabolites

[Grozinger, Karl G.; Byrne, Denis P.; Nummy, Laurence J.; Ridges, Michael D.; Salvagno, Annette Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 2 p. 229 - 239]

Synthesis of five nevirapine metabolites

[Grozinger, Karl G.; Byrne, Denis P.; Nummy, Laurence J.; Ridges, Michael D.; Salvagno, Annette Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 2 p. 229 - 239]

Synthesis of five nevirapine metabolites

[Grozinger, Karl G.; Byrne, Denis P.; Nummy, Laurence J.; Ridges, Michael D.; Salvagno, Annette Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 2 p. 229 - 239]

Synthesis of five nevirapine metabolites

[Grozinger, Karl G.; Byrne, Denis P.; Nummy, Laurence J.; Ridges, Michael D.; Salvagno, Annette Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 2 p. 229 - 239]

Synthesis of five nevirapine metabolites

[Grozinger, Karl G.; Byrne, Denis P.; Nummy, Laurence J.; Ridges, Michael D.; Salvagno, Annette Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 2 p. 229 - 239]