Design, Synthesis, Computational Prediction, and Biological Evaluation of Ester Soft Drugs as Inhibitors of Dihydrofolate Reductase from Pneumocystis c arinii

M Graffner-Nordberg, K Kolmodin, J Åqvist…

文献索引：Taylor, Edward C.; Otiv, S. R.; Durucasu, Inci Heterocycles, 1993 , vol. 36, # 8 p. 1883 - 1895

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被引用次数: 88

摘要

... Volume: Page: ... 32,36,38 Today, considerable research efforts are devoted to the identification of more selective and potent DHFR inhibitors with the ... a Reagents and conditions: (i) (a) H 2 , 10% Pd/C, Et 3 N, DMF, (b) guanidine hydrochloride, NaOMe, reflux; (ii ...