Unique sequence in deltorphin C confers structural requirement for δ opioid receptor selectivity

LH Lazarus, S Salvadori, P Grieco, WE Wilson…

文献索引：Lazarus, LH; Salvadori, S; Grieco, P; Wilson, WE; Tomatis, R European Journal of Medicinal Chemistry, 1992 , vol. 27, # 8 p. 791 - 797

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被引用次数: 13

摘要

Abstract A series of deltorphin C (H-Tyr-d-Ala-Phe-Asp-Val-Val-Gly-NH 2) analogues were synthesized to assess the consequences of changing anionic and hydrophobic residues on δ receptor selectivity. Analogues with altered C-terminal groups, inverted sequences, or esterified with tert-butyl, benzyl, or ethyl groups revealed that high δ selectivity required an unmodified amino acid sequence. Shifts of Asp and hydrophobic residues decreased δ ...