Investigation of the Mechanism of Action of Pyrogallol–Phloroglucinol Transhydroxylase by Using Putative Intermediates

…, U Bartlewski??Hof, J Rétey

文献索引：Paizs, Csaba; Bartlewski-Hof, Ulrike; Retey, Janos Chemistry - A European Journal, 2007 , vol. 13, # 10 p. 2805 - 2811

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被引用次数: 10

摘要

Abstract Pyrogallol–phloroglucinol transhydroxylase from Pelobacter acidigallici, a molybdopterin-containing enzyme, catalyzes a key reaction in the anaerobic degradation of aromatic compounds. In vitro, the enzymatic reaction requires 1, 2, 3, 5-tetrahydroxybenzene as a cocatalyst and the transhydroxylation occurs without exchange with hydroxy groups from water. To test our previous proposal that the transfer of the hydroxy group occurs via ...