Abstract A reductive amination/cyclization approach towards biologically interesting trifluoromethylated four-to seven-membered ring lactams from simply prepared ω- trifluoromethyl keto esters in good to excellent yields has been developed. In addition, trifluoromethylated δ-amino alcohols were also obtained directly from an unexpected reduction of the corresponding γ-imino esters in the presence of an excess amount of ...
