Reductive Amination/Cyclization of ω??Trifluoromethyl Keto Esters to Trifluoromethylated δ??Amino Alcohols and Lactams

…, J Hou, H Jiang, Z Yuan, G Ma, G Zhao…

Index: Wan, Wen; Hou, Jie; Jiang, Haizhen; Yuan, Zongqian; Goubin, Ma.; Zhao, Gang; Hao, Jian European Journal of Organic Chemistry, 2010 , # 9 p. 1778 - 1786

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Citation Number: 3

Abstract

Abstract A reductive amination/cyclization approach towards biologically interesting trifluoromethylated four-to seven-membered ring lactams from simply prepared ω- trifluoromethyl keto esters in good to excellent yields has been developed. In addition, trifluoromethylated δ-amino alcohols were also obtained directly from an unexpected reduction of the corresponding γ-imino esters in the presence of an excess amount of ...