Asymmetric hydrogenation of pyridines: enantioselective synthesis of nipecotic acid derivatives

A Lei, M Chen, M He, X Zhang

文献索引：Lei, Aiwen; Chen, Mao; He, Minsheng; Zhang, Xumu European Journal of Organic Chemistry, 2006 , # 19 p. 4343 - 4347

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被引用次数: 50

摘要

Abstract An asymmetric hydrogenation process of 3-substituted pyridine derivatives has been developed with the use of a Rh-TangPhos complex as the catalyst. The whole process consists of an efficient partial hydrogenation of nicotinate and a subsequent highly enantioselective, Rh-catalyzed, homogeneous hydrogenation. A series of chiral nipecotic acid derivatives have been synthesized.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 ...