Design, synthesis, and testing of potential antisickling agents. 5. Disubstituted benzoic acids designed for the donor site and proline salicylates designed for the …

DJ Abraham, DM Gazze, PE Kennedy…

文献索引：Abraham; Gazze; Kennedy; Mokotoff Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1549 - 1559

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被引用次数: 24

摘要

Donald J. Abraham,* David M. Gazze, Paul E. Kennedy, and Michael Mokotoff ... Department of Medicinal Chemistry, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261. Received February 29, 1984 ... This paper reports the discovery of a new class of potent antigelling agents. The new compounds, disubstituted benzoic acid derivatives, were designed by using molecular modeling experiments. These molecules contain functional groups ...