Design, synthesis, and testing of potential antisickling agents. 5. Disubstituted benzoic acids designed for the donor site and proline salicylates designed for the …

DJ Abraham, DM Gazze, PE Kennedy…

Index: Abraham; Gazze; Kennedy; Mokotoff Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1549 - 1559

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Citation Number: 24

Abstract

Donald J. Abraham,* David M. Gazze, Paul E. Kennedy, and Michael Mokotoff ... Department of Medicinal Chemistry, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261. Received February 29, 1984 ... This paper reports the discovery of a new class of potent antigelling agents. The new compounds, disubstituted benzoic acid derivatives, were designed by using molecular modeling experiments. These molecules contain functional groups ...