Synthesis of 2-amino-5-sulfanyl-1, 3, 4-thiadiazole derivatives and evaluation of their antidepressant and anxiolytic activity

…, M Guido, A Loche, V Perlini, M Brufani

文献索引：Clerici; Pocar; Guido; Loche; Perlini; Brufani Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 931 - 936

全文：HTML全文

被引用次数: 179

摘要

Recently a series of 2-amino-5-sulfanyl-1, 3, 4-thiadiazole derivatives bearing different substituents were synthesized and screened pharmacologically in order to evaluate their central nervous system activity. The purpose of this study was to evaluate the effects of the title compounds on CNS activity by varying the substituents in the thiadiazole moiety. It was found that some of these compounds possess marked antidepressant and anxiolytic ...