Synthesis of 2-amino-5-sulfanyl-1, 3, 4-thiadiazole derivatives and evaluation of their antidepressant and anxiolytic activity

…, M Guido, A Loche, V Perlini, M Brufani

Index: Clerici; Pocar; Guido; Loche; Perlini; Brufani Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 931 - 936

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Citation Number: 179

Abstract

Recently a series of 2-amino-5-sulfanyl-1, 3, 4-thiadiazole derivatives bearing different substituents were synthesized and screened pharmacologically in order to evaluate their central nervous system activity. The purpose of this study was to evaluate the effects of the title compounds on CNS activity by varying the substituents in the thiadiazole moiety. It was found that some of these compounds possess marked antidepressant and anxiolytic ...

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