Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors

R Sheng, X Lin, J Zhang, KS Chol, W Huang…

文献索引：Sheng, Rong; Lin, Xiao; Zhang, Jing; Chol, Kim Sun; Huang, Wenhai; Yang, Bo; He, Qiaojun; Hu, Yongzhou Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 18 p. 6692 - 6698

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被引用次数: 52

摘要

A new series of flavonoid derivatives have been designed, synthesized and evaluated as potent AChE inhibitors. Most of them showed more potent inhibitory activities to AChE than rivastigmine. The most potent inhibitor isoflavone derivative 10d inhibit AChE with a IC50 of 4nM and showed high BChE/AChE inhibition ratio (4575-fold), superior to donepezil (IC50= 12nM, 389-fold). Molecular docking studies were also performed to explore the detailed ...