Synthesis and evaluation of two uncharged 99mTc??labeled derivatives of thioflavin??T as potential tracer agents for fibrillar brain amyloid
…, D Vanderghinste, M Van Eeckhoudt…
文献索引：Serdons; Vanderghinste; Van Eeckhoudt; Cleynhens; De Groot; Bormans; Verbruggen Journal of Labelled Compounds and Radiopharmaceuticals, 2009 , vol. 52, # 6 p. 227 - 235
Abstract Thioflavin-T is a fluorescent dye for in vitro detection of fibrillar amyloid β, a protein found in the brain of patients suffering from Alzheimer's disease. We synthesized and biologically evaluated two uncharged 99m Tc-labeled derivatives of thioflavin-T. The precursors for labeling were synthesized by coupling an S, S′-bis-triphenylmethyl-N-tert- butoxycarbonyl bis-amino-bis-thiol tetradentate ligand via a propoxy spacer to 2-(4′- ...
