Abstract Thioflavin-T is a fluorescent dye for in vitro detection of fibrillar amyloid β, a protein found in the brain of patients suffering from Alzheimer's disease. We synthesized and biologically evaluated two uncharged 99m Tc-labeled derivatives of thioflavin-T. The precursors for labeling were synthesized by coupling an S, S′-bis-triphenylmethyl-N-tert- butoxycarbonyl bis-amino-bis-thiol tetradentate ligand via a propoxy spacer to 2-(4′- ...
