Simple C-2-substituted quinolines and their anticancer Activity

…, FA Rojas Ruiz, LY Vargas Mendez…

文献索引：Kouznetsov, Vladimir V.; Rojas Ruiz, Fernando A.; Vargas Mendez, Leonor Y.; Gupta, Mahabir P. Letters in Drug Design and Discovery, 2012 , vol. 9, # 7 p. 680 - 686

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被引用次数: 16

摘要

Sixteen C-2-substituted quinolines were tested in both human cancer cell lines (MCF-7, H- 460 and SF-268) and normal cell lines (Vero and THP-1). Preliminary results indicate that 2- α-furyl-and 2-γ-pyridinyl quinoline derivatives 1, 13 and 14 are active against three human cancer cell lines and, at the same time, were devoid of cytotoxic effect on normal cells. Biological activity and SAR results were compared with different molecular descriptors ...