Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase

S Ulmschneider, U Müller-Vieira…

文献索引：Almansa; Carceller; Bartroli; Forn Synthetic Communications, 1993 , vol. 23, # 21 p. 2965 - 2971

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被引用次数: 71

摘要

... by palladium-catalyzed cross coupling to yield the nitriles 3i, 4i, 5i as described by Almansa et al. ... 22 A novel synthetic pathway was pursued for the synthesis of the ketone 6i: 23 a Friedel−Crafts ... in the Wittig reaction with K 2 CO 3 as base (Scheme 4) to form the intermediates ...