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Convenient synthesis of methyl 1-methyl-2, 4-dibromo-5-imidazolecarboxylate

JF O'Connell, J Parquette, WE Yelle, W Wang…

文献索引:O'Connell, John F.; Parquette, Jonathan; Yelle, William E.; Wang, Wilhelm; Rapoport, Henry Synthesis, 1988 , # 10 p. 767 - 771

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被引用次数: 54

摘要

Raney Nickel could be effected without debromination and gave the 4-bromoimidazole ester 7. Now, bromination of the remaining open 2-position was easily achieved in 85% yield with NBS to give the dibromoimidazole ester 8. Despite an overall yield of only 12%, this ...