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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Search for antialcoholic agents in the series of amides of substituted pyrazole-4-carboxylic and pyrazole-4-acetic acids

VA Zagorevskii, NV Vlasova, DA Zykov…

文献索引：Zagorevskii, V. A.; Vlasova, N. V.; Zykov, D. A.; Kirsanova, Z. D. Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 8 p. 684 - 689 Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 8 p. 966 - 971

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被引用次数: 0

摘要

Intensified activity of ethanol-oxidizing enzymic systems (EOES) leads to considerable disturbance of metabolic processes, by a suddenly increased synthesis of acetaldehyde [9,! 0, 14, 15]. The activation of these systems in some cases predicates an attraction to alcohol, and is involved in the mechanism of obtaining a state of abstinence [3]. Based on this, a hypothesis was advanced of the possibility of using a pharmacological inhibiting action at ...

1,3-Diphenyl-1h-pyrazole-4-carbonyl chloride结构式

1,3-Diphenyl-1h...

~67%

1,3-diphenylpyrazole-4-carboxamide结构式

1,3-diphenylpyr...

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1,3-二苯基-1H-吡唑-4-羧酸结构式

1,3-二苯基-1H-吡唑-4-羧酸

~%

1,3-diphenylpyrazole-4-carboxamide结构式

1,3-diphenylpyr...

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异戊胺结构式

1,3-diphenyl-5-methylpyrazole-4-carboxylic chloride结构式

1,3-diphenyl-5-...

~70%

1,3-Diphenyl-5-methyl-N-(3-methylbutyl)-1H-pyrazole-4-carboxamide结构式

1,3-Diphenyl-5-...

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5-甲基-1,3-二苯-1H-吡唑-4-羧酸结构式

5-甲基-1,3-二苯-1H-...

~%

1,3-Diphenyl-5-methyl-N-(3-methylbutyl)-1H-pyrazole-4-carboxamide结构式

1,3-Diphenyl-5-...

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(3,5-二甲基-1-苯基-1H-吡唑-4-基)乙酸结构式

(3,5-二甲基-1-苯基-1...

~%

N-benzyl-2-(3,5-dimethyl-1-phenylpyrazol-4-yl)acetamide结构式

N-benzyl-2-(3,5...

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(3,5-二甲基-1-苯基-1H-吡唑-4-基)乙酸结构式

(3,5-二甲基-1-苯基-1...

~%

2-(3,5-dimethyl-1-phenylpyrazol-4-yl)-1-piperidin-1-ylethanone结构式

2-(3,5-dimethyl...

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(3,5-二甲基-1-苯基-1H-吡唑-4-基)乙酸结构式

(3,5-二甲基-1-苯基-1...

~%

2-(3,5-dimethyl-1-phenyl-pyrazol-4-yl)-N,N-dipropan-2-yl-acetamide结构式

2-(3,5-dimethyl...

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二异丙胺结构式

1,3-diphenyl-5-methylpyrazole-4-carboxylic chloride结构式

1,3-diphenyl-5-...

~85%

5-methyl-1,3-diphenyl-N,N-di(propan-2-yl)pyrazole-4-carboxamide结构式

5-methyl-1,3-di...

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5-甲基-1,3-二苯-1H-吡唑-4-羧酸结构式

5-甲基-1,3-二苯-1H-...

~%

5-methyl-1,3-diphenyl-N,N-di(propan-2-yl)pyrazole-4-carboxamide结构式

5-methyl-1,3-di...

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2-氨基乙醇结构式

1,3-diphenyl-5-methylpyrazole-4-carboxylic chloride结构式

1,3-diphenyl-5-...

~49%

N-(2-hydroxyethyl)-5-methyl-1,3-diphenylpyrazole-4-carboxamide结构式

N-(2-hydroxyeth...

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5-甲基-1,3-二苯-1H-吡唑-4-羧酸结构式

5-甲基-1,3-二苯-1H-...

~%

N-(2-hydroxyethyl)-5-methyl-1,3-diphenylpyrazole-4-carboxamide结构式

N-(2-hydroxyeth...

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正丁胺结构式

1,3-diphenyl-5-methylpyrazole-4-carboxylic chloride结构式

1,3-diphenyl-5-...

~82%

N-butyl-5-methyl-1,3-diphenylpyrazole-4-carboxamide结构式

N-butyl-5-methy...

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5-甲基-1,3-二苯-1H-吡唑-4-羧酸结构式

5-甲基-1,3-二苯-1H-...

~%

N-butyl-5-methyl-1,3-diphenylpyrazole-4-carboxamide结构式

N-butyl-5-methy...

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(3,5-二甲基-1-苯基-1H-吡唑-4-基)乙酸结构式

(3,5-二甲基-1-苯基-1...

~%

N-tert-butyl-2-(3,5-dimethyl-1-phenylpyrazol-4-yl)acetamide结构式

N-tert-butyl-2-...

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二正丙胺结构式

1,3-diphenyl-5-methylpyrazole-4-carboxylic chloride结构式

1,3-diphenyl-5-...

~59%

1,3-Diphenyl-N,N-dipropyl-5-methyl-1H-pyrazole-4-carboxamide结构式

1,3-Diphenyl-N,...

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5-甲基-1,3-二苯-1H-吡唑-4-羧酸结构式

5-甲基-1,3-二苯-1H-...

~%

1,3-Diphenyl-N,N-dipropyl-5-methyl-1H-pyrazole-4-carboxamide结构式

1,3-Diphenyl-N,...

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苄胺结构式

1,3-diphenyl-5-methylpyrazole-4-carboxylic chloride结构式

1,3-diphenyl-5-...

~71%

N-benzyl-5-methyl-1,3-diphenylpyrazole-4-carboxamide结构式

N-benzyl-5-meth...

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5-甲基-1,3-二苯-1H-吡唑-4-羧酸结构式

5-甲基-1,3-二苯-1H-...

~%

N-benzyl-5-methyl-1,3-diphenylpyrazole-4-carboxamide结构式

N-benzyl-5-meth...

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1-苄基哌嗪结构式

1,3-Diphenyl-1h-pyrazole-4-carbonyl chloride结构式

1,3-Diphenyl-1h...

~71%

(4-benzylpiperazin-1-yl)-(1,3-diphenylpyrazol-4-yl)methanone,hydrochloride结构式

(4-benzylpipera...

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1,3-二苯基-1H-吡唑-4-羧酸结构式

1,3-二苯基-1H-吡唑-4-羧酸

~%

(4-benzylpiperazin-1-yl)-(1,3-diphenylpyrazol-4-yl)methanone,hydrochloride结构式

(4-benzylpipera...

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吗啉结构式

1,3-diphenyl-5-methylpyrazole-4-carboxylic chloride结构式

1,3-diphenyl-5-...

~70%

(5-methyl-1,3-diphenylpyrazol-4-yl)-morpholin-4-ylmethanone结构式

(5-methyl-1,3-d...

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5-甲基-1,3-二苯-1H-吡唑-4-羧酸结构式

5-甲基-1,3-二苯-1H-...

~%

(5-methyl-1,3-diphenylpyrazol-4-yl)-morpholin-4-ylmethanone结构式

(5-methyl-1,3-d...

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(3,5-二甲基-1-苯基-1H-吡唑-4-基)乙酸结构式

(3,5-二甲基-1-苯基-1...

~%

2-(3,5-dimethyl-1-phenylpyrazol-4-yl)-N-(2-phenylethyl)acetamide结构式

2-(3,5-dimethyl...

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