Helvetica chimica acta

Photochemical synthesis of highly functionalized cyclopropyl ketones

P Wessig, O Muehling

文献索引：Wessig, Pablo; Muehling, Olaf Helvetica Chimica Acta, 2003 , vol. 86, # 3 p. 865 - 893

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被引用次数: 29

摘要

Abstract A series of di-and trisubstituted cyclopropyl ketones 11 were prepared by irradiation of ketones 3 and 5, which bear a leaving group adjacent to the carbonyl C-atom. The required ketones 3 could be easily synthesized either by functionalization of ketones 1 with a hypervalent iodine reagent, 2, or by O-sulfonylation of α-hydroxy ketones 7. The nitrates 5 were obtained by treatment of the corresponding α-bromo ketones with AgNO 3. The ...