N2-(4-Substituted-2, 6-dichlorophenyl)-N1, N1-dimethylformamidines as antihypertensive and diuretic agents

WE Meyer, AS Tomcufcik, PS Chan…

文献索引：Meyer, Walter E.; Tomcufcik, Andrew S.; Chan, Peter S.; Emma, John E. Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1705 - 1710

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被引用次数: 4

摘要

The synthesis of a series of fl-[4-[(arylmethyl) amino]-2, 6-dichlorophenyl]-~~- dimethylformamidines that caused marked blood pressure lowering and/or diuresis in spontaneously hypertensive rats (SHR) is reported. Diuretic activity was not always associated with acute antihypertensive activity. Central nervous system effects, most notably sedation, were observed. Compound 9d, which lowered arterial blood pressure 37 mmHg ...