Organic & biomolecular chemistry

Palladium-catalyzed tandem reaction to construct benzo [c] phenanthridine: application to the total synthesis of benzo [c] phenanthridine alkaloids

P Lv, K Huang, L Xie, X Xu

文献索引：Lv, Pei; Huang, Kanglun; Xie, Longguan; Xu, Xiaohua Organic and Biomolecular Chemistry, 2011 , vol. 9, # 9 p. 3133 - 3135

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被引用次数: 31

摘要

A concise and efficient synthesis of benzo [c] phenanthridines was accomplished by the palladium-catalyzed ring-opening coupling of azabicyclic alkene with o-iodobenzoates, followed by tandem cyclization. The strategy was successfully applied in the total synthesis of benzo [c] phenanthridine alkaloids such as sanguinarine, chelerythrine, nitidine and avicine.