ARKIVOC

The reaction of hydroxylamine with aspirin

…, BS Souza, ES Orth, TAS Brandão, W Rocha, AJ Kirby…

文献索引：Medeiros, Michelle; Souza, Bruno S.; Orth, Elisa S.; Brandao, Tiago A. S.; Rocha, Willian; Kirby, Anthony J.; Nome, Faruk Arkivoc, 2011 , vol. 2011, # 7 p. 461 - 476

全文：HTML全文

被引用次数: 0

摘要

Abstract Hydroxylamine reacts with aspirin in aqueous solution at 25 C predominantly through oxygen, to give O-acetylhydroxylamine as the initial product (Scheme 3). The reaction is much faster than the intramolecular general base catalysed hydrolysis of the carboxylate anion, as it is also for the CO2H form of aspirin. Both reactions are faster than expected, consistent with moderate activation and/or proton transfer catalysis of ...