Abstract Some new N-substituted acetyl derivatives of 2-amino-5-alkyl-1, 3, 4-thiadiazoles have been prepared and investigated for antihistaminic and spasmolytic activity on guine pig ileum. A few of the compounds showed encouraging effects. In addition, some of the compounds also showed anti-inflammatory activity.
![2-[benzyl(methyl)amino]-N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide结构式](https://image.chemsrc.com/caspic/397/141400-70-6.png)
![2-[2-methyl-4-(5-methyl-1,3,4-thiadiazol-2-yl)piperazin-1-yl]acetamide结构式](https://image.chemsrc.com/caspic/290/141400-68-2.png)
![2-[butyl(methyl)amino]-N-(5-ethyl-1,3,4-thiadiazol-2-yl)acetamide结构式](https://image.chemsrc.com/caspic/452/141400-64-8.png)
