European journal of medicinal chemistry

Synthesis and biological evaluation of 2-[substituted acetyl] amino-5-alkyl-1, 3, 4-thiadiazoles

AK Shakya, GK Patnaik, P Mishra

Index: Shakya; Patnaik; Mishra European Journal of Medicinal Chemistry, 1992 , vol. 27, # 1 p. 67 - 71

Full Text: HTML

Citation Number: 13

Abstract

Abstract Some new N-substituted acetyl derivatives of 2-amino-5-alkyl-1, 3, 4-thiadiazoles have been prepared and investigated for antihistaminic and spasmolytic activity on guine pig ileum. A few of the compounds showed encouraging effects. In addition, some of the compounds also showed anti-inflammatory activity.

 Related Synthetic Route
N-Methylbenzylamine Structure

103-67-3

N-Methylbenzylamine

Acetamide,2-chloro-N-(5-methyl-1,3,4-thiadiazol-2-yl)- Structure

21521-87-9

Acetamide,2-chl...

~51%

2-[benzyl(methyl)amino]-N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide Structure

141400-70-6

2-[benzyl(methy...

2-Amino-5-methyl-1,3,4-thiadiazole Structure

108-33-8

2-Amino-5-methy...

Chloroacetyl chloride Structure

79-04-9

Chloroacetyl ch...

~90%

Acetamide,2-chloro-N-(5-methyl-1,3,4-thiadiazol-2-yl)- Structure

21521-87-9

Acetamide,2-chl...

2-Pipecoline Structure

109-05-7

2-Pipecoline

Acetamide,2-chloro-N-(5-methyl-1,3,4-thiadiazol-2-yl)- Structure

21521-87-9

Acetamide,2-chl...

~63%

2-(2-methylpiperidin-1-yl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide Structure

141400-66-0

2-(2-methylpipe...

methylpiperazine Structure

109-01-3

methylpiperazine

2-CHLORO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-ACETAMIDE Structure

21521-90-4

2-CHLORO-N-(5-E...

~45%

N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-(4-methylpiperazin-1-yl)acetamide Structure

141400-69-3

N-(5-ethyl-1,3,...

5-ethyl-1,3,4-thiadiazol-2-amine Structure

14068-53-2

5-ethyl-1,3,4-t...

Chloroacetyl chloride Structure

79-04-9

Chloroacetyl ch...

~89%

2-CHLORO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-ACETAMIDE Structure

21521-90-4

2-CHLORO-N-(5-E...

Piperidine Structure

110-89-4

Piperidine

2-CHLORO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-ACETAMIDE Structure

21521-90-4

2-CHLORO-N-(5-E...

~57%

N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-piperidin-1-ylacetamide Structure

111750-47-1

N-(5-ethyl-1,3,...

methylpiperazine Structure

109-01-3

methylpiperazine

Acetamide,2-chloro-N-(5-methyl-1,3,4-thiadiazol-2-yl)- Structure

21521-87-9

Acetamide,2-chl...

~36%

2-[2-methyl-4-(5-methyl-1,3,4-thiadiazol-2-yl)piperazin-1-yl]acetamide Structure

141400-68-2

2-[2-methyl-4-(...

Piperazine Structure

110-85-0

Piperazine

2-CHLORO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-ACETAMIDE Structure

21521-90-4

2-CHLORO-N-(5-E...

~50%

N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-piperazin-1-ylacetamide Structure

141400-73-9

N-(5-ethyl-1,3,...

N-Methylbutylamine Structure

110-68-9

N-Methylbutylamine

2-CHLORO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-ACETAMIDE Structure

21521-90-4

2-CHLORO-N-(5-E...

~70%

2-[butyl(methyl)amino]-N-(5-ethyl-1,3,4-thiadiazol-2-yl)acetamide Structure

141400-64-8

2-[butyl(methyl...

Piperidine Structure

110-89-4

Piperidine

Acetamide,2-chloro-N-(5-methyl-1,3,4-thiadiazol-2-yl)- Structure

21521-87-9

Acetamide,2-chl...

~50%

N-(5-methyl-1,3,4-thiadiazol-2-yl)-2-piperidin-1-ylacetamide Structure

141400-65-9

N-(5-methyl-1,3...

Piperazine Structure

110-85-0

Piperazine

Acetamide,2-chloro-N-(5-methyl-1,3,4-thiadiazol-2-yl)- Structure

21521-87-9

Acetamide,2-chl...

~51%

N-(5-methyl-1,3,4-thiadiazol-2-yl)-2-piperazin-1-ylacetamide Structure

141400-72-8

N-(5-methyl-1,3...


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