Preparation and antiarthritic activity of new 1, 5-diaryl-3-alkylthio-1H-1, 2, 4-triazoles and corresponding sulfoxides and sulfones

G Szilágyi, T Somorai, É Bozó, J Langó, G Nagy…

文献索引：Szilagyi, Geza; Somorai, Tamas; Bozo, Eva; Lango, Jozsef; Nagy, Gabor; et al. European Journal of Medicinal Chemistry, 1990 , vol. 25, # 2 p. 95 - 101

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被引用次数: 20

摘要

Abstract A series of 1, 5-diaryl-3-alkylthio-1H-1, 2, 4-triazoles and corresponding sulfoxides and sulfones was synthesized and evaluated as antiinflammatory agents in the rat adjuvant induced arthritis assay. Several analogues were found to be more potent than phenylbutazone and naproxen. Structure-activity relationships are discussed.