A series of 5, bdisubstituted hydantoin derivatives was synthesized by alkylating 5, 5-bis (mercaptomethy1)-2, 4-imidazolidinedione (3) with various halomethylaromatic or halomethylheteroaromatic precursors, or by using the Buchener-Berg procedure on the required ketone. When evaluated for their ability to inhibit HIV-induced cell killiig and virus production in CEM or MT-2 cells only compounds 2, 4n, 40, and 4i demonstrated modest ...
![4-[[4-[(4-carboxyphenyl)methylsulfanylmethyl]-2,5-dioxoimidazolidin-4-yl]methylsulfanylmethyl]benzoic acid结构式](https://image.chemsrc.com/caspic/484/142979-84-8.png)
