5, 5-Disubstituted hydantoins: syntheses and anti-HIV activity

RN Comber, RC Reynolds, JD Friedrich…

Index: Comber, Robert N.; Reynolds, Robert C.; Friedrich, Joyce D.; Manguikian, Roupen A.; Buckheit, Robert W.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 19 p. 3567 - 3572

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Citation Number: 72

Abstract

A series of 5, bdisubstituted hydantoin derivatives was synthesized by alkylating 5, 5-bis (mercaptomethy1)-2, 4-imidazolidinedione (3) with various halomethylaromatic or halomethylheteroaromatic precursors, or by using the Buchener-Berg procedure on the required ketone. When evaluated for their ability to inhibit HIV-induced cell killiig and virus production in CEM or MT-2 cells only compounds 2, 4n, 40, and 4i demonstrated modest ...