A general synthetic route for preparing ether phospholipids suitable for immobilization: a phosphotriester approach

…, S Ong, C Bernal, D Rhee, C Pidgeon

文献索引：Qiu, Xiaoxing; Ong, Shaowei; Bernal, Candido; Rhee, Dongmi; Pidgeon, Charles Journal of Organic Chemistry, 1994 , vol. 59, # 3 p. 537 - 543

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被引用次数: 26

摘要

A synthetic route was developed to prepare ether phospholipid (PL) ligands suitable for immobilization. PL ligand design included an w-carboxyl functional group to assure proper molecular orientation during immobilization; Le., the polar lipid head group protrudes from the surface. However, during immobilization, PL ligands required protecting groups to eliminate the possibility of the PL binding upside down. Four synthetic PL ligands were ...