Abstract Convenient syntheses of aryl diselenides 2, 1, 2-benzisoselenazol-3 (2H)-ones 4 and their 1-oxides 7 are reported. Reductive conversions of these compounds to bis (2- carbamoyl)-phenyl diselenides 5 and oxidative cyclization of 5 to 1, 2-benzisoselenazol-3 (2H)-one 1-oxides 7 as the methods for the synthesis of these compounds are reported. Their ability to induce cytokines, such as TNF and IFN-γ, in human peripheral blood ...