Aromatic and azaaromatic diselenides, benzisoselenazolones and related compounds as immunomodulators active in humans: synthesis and properties

…, K Kloc, L Syper, AD Inglot, E Piasecki

Index: Mlochowski, Jacek; Kloc, Krystian; Syper, Ludwik; Inglot, Anna D.; Piasecki, Egbert Liebigs Annalen der Chemie, 1993 , # 12 p. 1239 - 1244

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Citation Number: 52

Abstract

Abstract Convenient syntheses of aryl diselenides 2, 1, 2-benzisoselenazol-3 (2H)-ones 4 and their 1-oxides 7 are reported. Reductive conversions of these compounds to bis (2- carbamoyl)-phenyl diselenides 5 and oxidative cyclization of 5 to 1, 2-benzisoselenazol-3 (2H)-one 1-oxides 7 as the methods for the synthesis of these compounds are reported. Their ability to induce cytokines, such as TNF and IFN-γ, in human peripheral blood ...