Tetrahedron letters

An efficient method for chlorination of alcohols using PPh 3/Cl 3 CCONH 2

W Pluempanupat, W Chavasiri

文献索引：Pluempanupat, Wanchai; Chavasiri, Warinthorn Tetrahedron Letters, 2006 , vol. 47, # 38 p. 6821 - 6823

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被引用次数: 33

摘要

A new and convenient method for the chlorination of alcohols utilizing PPh3/Cl3CCONH2 is addressed. Various alcohols could smoothly be converted into their corresponding alkyl chlorides in high yield under mild conditions with short reaction times. A mechanism is disclosed with the evidence of inversion of configuration of the analogous alkyl chloride derived from R-(−)-2-octanol.