Synthesis and antituberculosis activity of new fatty acid amides

…, R da Costa Duarte, PA da Silva, MGM D'Oca

文献索引：D'Oca, Caroline Da Ros Montes; Coelho, Tatiane; Marinho, Tamara Germani; Hack, Carolina Rosa Lopes; Da Costa Duarte, Rodrigo; Da Silva, Pedro Almeida; D'Oca, Marcelo Gonalves Montes Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 17 p. 5255 - 5257

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被引用次数: 32

摘要

This work reports the synthesis of new fatty acid amides from C16: 0, 18: 0, 18: 1, 18: 1 (OH), and 18: 2 fatty acids families with cyclic and acyclic amines and demonstrate for the first time the activity of these compounds as antituberculosis agents against Mycobacterium tuberculosis H37Rv, M. tuberculosis rifampicin resistance (ATCC 35338), and M. tuberculosis isoniazid resistance (ATCC 35822). The fatty acid amides derivate from ...