The diuretic activity of representative benzenedisulfonamides has been reported previously. 112, 3 Compounds of greatest interest lie in the meta series, derivatives of benzene-l, 3disulfonamide. The activity is markedly influenced by further substitution in the benzene ring; halogen, amino, and acylamino groups were found to be particularly desirable. The preparation and some of the structure-activity relations of a series of ...