Synthesis of N-propargylphenelzine and analogues as neuroprotective agents

…, LJ Urichuk, BD Sloley, RT Coutts, GB Baker…

文献索引：Ling, Lei; Urichuk, Liana J.; Sloley; Coutts, Ronald T.; Baker, Glen B.; Shan, Jacqueline J.; Pang, Peter K.T. Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 20 p. 2715 - 2717

全文：HTML全文

被引用次数: 31

摘要

A series of N1-and N2-propargylphenelzine derivatives and analogues (1–7) was synthesized. In addition to their activity as monoamine oxidase inhibitors, two of the compounds, N1-and N2-propargylphenelzines (3 and 6), were found to be potent at preventing DSP-4-induced noradrenaline (NA) depletion in mouse hippocampus, suggesting that they have neuroprotective properties.