Design, synthesis and molecular docking of amide and urea derivatives as Escherichia coli PDHc-E1 inhibitors

…, QS Sun, GY You, L Zhang, P Zou, LL Feng…

文献索引：He, Jun-Bo; Ren, Yan-Liang; Sun, Qiu-Shuang; You, Ge-Yun; Zhang, Li; Zou, Peng; Feng, Ling-Ling; Wan, Jian; He, Hong-Wu Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 12 p. 3180 - 3186

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被引用次数: 4

摘要

Abstract By targeting the ThDP binding site of Escherichia coli PDHc-E1, two new 'open- chain'classes of E. coli PDHc-E1 inhibitors, amide and urea derivatives, were designed, synthesized, and evaluated. The amide derivatives of compound 6d, with 4-NO 2 in the benzene ring, showed the most potent inhibition of E. coli PDHc-E1. The urea derivatives displayed more potent inhibitory activity than the corresponding amide derivatives with the ...