Synthesis and antiviral activity of certain 4-and 4, 5-disubstituted 7-[(2-hydroxyethoxy) methyl] pyrrolo [2, 3-d] pyrimidines

JS Pudlo, NK Saxena, MR Nassiri…

文献索引：Pudlo, Jeffrey S.; Saxena, Naveen K.; Nassiri, M. Reza; Turk, Steven R.; Drach, John C.; Townsend, Leroy B. Journal of Medicinal Chemistry, 1988 ,  vol. 31,  # 11  p. 2086 - 2092

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被引用次数: 40

摘要

In vitro evaluation of a series of previously prepared tubercidin analogues revealed that certain 5-halogen-substituted analogues were active against human cytomegalovirus (HCMV) at concentrations lower than those that produced comparable cytotoxicity in uninfected cells. In contrast, tubercidin was cytotoxic at all antiviral concentrations. Even though the antiviral selectivity of the 5-substituted compounds was slight, this observation ...