Synthesis and antiviral activity of certain 4-and 4, 5-disubstituted 7-[(2-hydroxyethoxy) methyl] pyrrolo [2, 3-d] pyrimidines

JS Pudlo, NK Saxena, MR Nassiri…

Index: Pudlo, Jeffrey S.; Saxena, Naveen K.; Nassiri, M. Reza; Turk, Steven R.; Drach, John C.; Townsend, Leroy B. Journal of Medicinal Chemistry, 1988 ,  vol. 31,  # 11  p. 2086 - 2092

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Citation Number: 40

Abstract

In vitro evaluation of a series of previously prepared tubercidin analogues revealed that certain 5-halogen-substituted analogues were active against human cytomegalovirus (HCMV) at concentrations lower than those that produced comparable cytotoxicity in uninfected cells. In contrast, tubercidin was cytotoxic at all antiviral concentrations. Even though the antiviral selectivity of the 5-substituted compounds was slight, this observation ...