Electrophilic intermediate in the reaction of glutathione and nitroso arenes

S Kazanis, RA McClelland

文献索引：Kazanis, Sophia; McClelland, Robert A. Journal of the American Chemical Society, 1992 , vol. 114, # 8 p. 3052 - 3059

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被引用次数: 83

摘要

Abstract: A kinetic study is reported of the reaction of glutathione (yL-glutamyl-L- cysteinylglycine, GSH) with nine substituted nitrosobenzenes (3, 4-Me2, 4-Me, 3, 5-Me2, 3- Me, parent, 3-Me0, 4-CI, 3-C1, 3-N02). Previous workers have shown that this reaction proceeds in parallel pathways, producing the appropriate N-arylhydroxylamine and GSSG or a sulfinanilide adduct ArNHS (0) G; a rapid equilibrium addition to form a common ...