Synthesis of cephalotaxine esters and correlation of their structures with antitumor activity

KL Mikolajczak, CR Smith Jr…

文献索引：Mikolajczak,K.L. et al. Journal of Medicinal Chemistry, 1977 , vol. 20, p. 328 - 332

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被引用次数: 16

摘要

Twenty-two new esters of natural (-)-cephalotaxine with synthetic acids possessing widely divergent structural features have been synthesized. Murine antitumor (P388 system) test data reveal that the methyl itaconate (7a) and trichloroethyl carbonate (27) esters of cephalotaxine are the most active of this group; this activity is less than that of harringtonine and other naturally occurring cephalotaxine esters. Other synthetic esters exhibiting ...