Design and synthesis of HCV agents with sequential triple inhibitory potentials

…, MB Fawzi, M Flint, F Kong, J Szeliga, R Tsao…

文献索引：Zhu, Tianmin; Fawzi, Mahdi B.; Flint, Michael; Kong, Fangming; Szeliga, Jan; Tsao, Russ; Howe, Anita Y.M.; Pan, Weitao Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 17 p. 5212 - 5216

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被引用次数: 8

摘要

Hepatitis C is a serious world wide health problem caused by RNA virus—hepatitis C virus infection that infects about 170 million people. 1 Failed treatment or under treatment, which is not uncommon due to its asymptotic nature, leads to chronic hepatitis C. 1 Chronic hepatitis C, defined as hepatitis C virus persisting for more than six months, can cause chronic liver inflammation that can develop into cirrhosis and cancer, and is the most common reason for liver transplantation. While ...