Synthesis of a 5-((Aryloxy) methyl)-3-(4-(trifluoromethyl) phenyl)[1, 2, 4] thiadiazole Derivative: A Promising PPARα, δ Agonist

…, RK Russell, L Shen, S Youells, Y Zhang

文献索引：Reuman, Michael; Hu, Zhiyong; Kuo, Gee-Hong; Li, Xun; Russell, Ronald K.; Shen, Lan; Youells, Scott; Zhang, Yongzheng Organic Process Research and Development, 2007 , vol. 11, # 6 p. 1010 - 1014

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被引用次数: 6

摘要

The preparation of the PPARα, δ agonist 2-methyl-2-(2-methyl-4-(3-(4-(trifluoromethyl) phenyl)[1, 2, 4] thiadiazol-5-ylmethoxy) phenoxy) propionic acid sodium salt (17) is described and compared with earlier in-house preparations of this important target ...