Bisubstrate inhibitors of biotin protein ligase in Mycobacterium tuberculosis resistant to cyclonucleoside formation

C Shi, D Tiwari, DJ Wilson, CL Seiler…

文献索引：Reuter, Deborah C.; McIntosh, Joel E.; Guinn, Ashley C.; Madera, Ann Marie Synthesis, 2003 , # 15 p. 2321 - 2324

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被引用次数: 6

摘要

... The 2-alkynyl analogue 13 was synthesized from 2-iodoadenosine 28, prepared in 5 steps from guanosine (Scheme 4).(26) Sonogashira coupling was then performed to ... figure Scheme 4. Synthesis of 13 a. ... (d) biotin–NHS, Cs 2 CO 3 , DMF, 0 → 25 °C; (e) 50% aqueous TFA, 0 ...