Development of a large scale asymmetric synthesis of vanilloid receptor (TRPV1) antagonist ABT-102

…, B Kotecki, CJ Venkatramani, MR Leanna

文献索引：Lukin, Kirill; Hsu, Margaret C.; Chambournier, Gilles; Kotecki, Brian; Venkatramani; Leanna Organic Process Research and Development, 2007 , vol. 11, # 3 p. 578 - 584

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被引用次数: 13

摘要

A highly efficient asymmetric synthesis of TRPV1 antagonist ABT-102 was developed and successfully demonstrated on a multi-kilogram scale. This process incorporates a new asymmetric synthesis of (R)-tert-butylaminoindan, which is based on a chiral auxiliary induced diastereoselective reduction of its iminoindan precursor.